What is the difference between totipotent, pluripotent, and multipotent? | NYSTEM - multipotent adult


multipotent adult

Multipotent cells can develop into more than one cell type, but are more limited than pluripotent cells; adult stem cells and cord blood stem cells are considered multipotent.

BACKGROUND: Multipotent adult progenitor cells are a bone marrow-derived, allogeneic, cell therapy product that modulates the immune system, and represents a promising therapy for acute stroke.

Jul 08, 2013 · There are lots of multipotent stem cells in the adult human body. They reside in the bone marrow, skin, muscle, GI tract, endothelium, and mesenchymal tissues. This means that there is a nice source for replacing cells that have died or been sloughed away.

Multipotent adult progenitor cells and related cell types have been shown to modulate the inflammatory response after spinal cord injury, driving macrophages toward an alternatively activated phenotype and reducing the effects of the inhibitory glial scar,. DePaul et al. demonstrated that intravenous delivery of hMAPCs in an acute contusive spinal cord injury model reduced macrophage-mediated axonal cell .